About Carmine Therapeutics
Carmine Therapeutics is an Esco Ventures X company pioneering a powerful new class of drugs based on engineered red blood cells extracellular vesicles (RBCEVs), founded by Esco Ventures and Professors Harvey Lodish, Minh Le, and Jiahai Shi. Carmine's proprietary Red Cell EV Gene Therapy (REGENT™) platform is positioned to address some of the unmet technological needs related to the delivery of next-generation therapeutic modalities such as nucleic acids. Carmine was awarded the 2019 Bristol-Myers Squibb's Golden Ticket to LabCentral (Cambridge, MA) and has established a research collaboration with Takeda Pharmaceuticals in a deal worth over $900M USD. The Company is well-capitalized to develop next-generation non-viral gene therapies to overcome most AAV-based gene therapy limitations. Carmine is based both in Cambridge, MA, and Singapore.

About the Role
The CMC Team in Cambridge is looking for a Senior Scientist or Principal Scientist to develop and implement purification schemes for RBCEVs. Reporting to the VP of CMC, this position will nucleate a downstream purification development team at Carmine and will create phase-appropriate purification processes for RBCEV development candidates.

Responsibilities

Design and execute experimental plans in coordination with development objectives of the CMC team, which are initially to develop scalable purification processes for loaded and unloaded RBCEVs
Assist in the recruitment, oversight, and mentoring of a team of scientists and research associates to develop a purification team within CMC
Stay abreast of the latest scientific and competitive developments for EV purification and apply this knowledge to both team strategy and incoming development candidates
Regularly communicate results to project teams and senior leadership; prepare presentations, reports, patent filings and external communications as required
Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders
Maintain and manage external CMO relationships with commercial partners
Support the continued creation and expansion of company’s intellectual property
Perform other related duties incidental to the work described herein

Experience & Qualifications

An experienced purification scientist with a Ph.D. in bioengineering or a related scientific discipline and a minimum of 5 years of experience in purification in an industry setting, with novel modality experience preferred
Exceptional candidates with a M.S. in bioengineering or a related scientific discipline and a minimum of 7-10 years of experience may also be considered
Demonstrated record of success with strong publication record or patent filings
Experience in leading cross-functional teams in a CMC setting
Experience in the following would be an asset: AKTA purification of multiple biological modalities, UF/DF or TFF experience with larger biological modalities (e.g. viruses), and tech transfer of developed processes to a manufacturing setting
Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage
Team oriented, highly motivated, execution focused with strong work ethic, ability to thrive in an entrepreneurial and multidisciplinary environment