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Laboratory Associate, Biology

New Haven, CT · Science/Research
ABOUT ARTIZAN BIOSCIENCES: Artizan Biosciences is a growth-stage biotechnology company that utilizes a proprietary platform to identify critical microorganisms in our intestinal microbiota that play causative roles in important human diseases.  Using our technology, we define the specific mechanisms by which these organisms promote disease and then develop effective therapeutics to block these pathogenic processes. Through this approach, we are creating a portfolio of therapeutic agents that address important areas of unmet medical need in an unprecedented manner.  Artizan Biosciences was founded by leading Yale immunologists and is currently located at Science Park in New Haven, adjacent to the Yale University campus and within a growing biotech community.  We are seeking additional talented scientists to join our team and help us deliver on the promise of our approach.
 
ABOUT THE POSITION: We are seeking a full-time Research Associate to conduct research into the host targets affected by pathogenic organisms. The position entails working with a small and dedicated group of scientist in the fields of microbiology, immunology and microbiome research to develop novel therapeutics. The successful candidate will have relevant educational and practical experience and will actively participate in the laboratory’s important research in a dynamic team setting. In addition to versatility within the laboratory setting, this role requires a high level of self-motivation, responsibility, and an ability to quickly gain new skills. The candidate must be capable of working independently as well as in a team environment.
 
KEY RESPONSIBILITIES:
  • Establish, optimize, and conduct various in vitro, ex vivo, and in vivo assays to screen, prioritize, and validate therapeutic candidates
  • Plan and perform immunology, biochemistry, and molecular biology experiments with guidance
  • Perform basic microbiology tasks (culturing, CFU count, stock generation)
  • Perform immune phenotyping using multi-color flow cytometry and ELISA
  • Work with various pre-clinical models of colitis in specific pathogen-free and gnotobiotic settings
  • Conduct laboratory work and documentation according to SOPs
  • Maintain proper records and laboratory compliance in accordance with SOPs and safety policies
  • Troubleshoot and complete routine procedures independently and efficiently
 
KEY SKILLS AND EXPERIENCE:
  • Minimum 2 years of experience with mammalian cell culture (primary immune cells and cancer or immortalized cell lines)
  • Experience with organoid systems or Transwell system is a plus
  • In vivo procedures with rodents such as handling (gavage, injection, husbandry) and dissection
  • Experience with primary immune cell isolation from mucosal tissue is a plus
  • Minimum 2 years of standard biochemistry procedures such as western blot analysis
  • Minimum 2 years of standard molecular biology procedures (PCR, gel electrophoresis, qPCR)
  • Experience with basic immunology techniques such as ELISA and flow cytometry
  • Excellent research record-keeping practices
  • Flexibility to learn and adapt to new procedures
  • High motivation with a sense of urgency and responsibility
 
MINIMUM QUALIFICATIONS:
  • Master’s degree, or bachelor’s degree with significant experience in biological sciences or related subject
  • Three years of biomedical research experience (preferably industry) in drug discovery or basic cell biology
  • Excellent organization

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