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Sr. Scientist, Fermentation Process Development

Cambridge, MA · Science/Research
At Synlogic: We are Putting LIFE Into Medicines.
 
We are pioneers in the development of Synthetic BioticTM medicines, a novel class of LIVING medicines intended to transform the lives of patients with a broad range of diseases ranging from genetic and acquired metabolic diseases to inflammation and cancer. 
 
Every day our teams work tirelessly to drive to deliver on 4 aspirations:  
  • People:  LIVING each day with passion for building up and building out our Synlogic team
  • Platform:  Expanding and enhancing the technology to generate and protect novel LIVING medicines with new and versatile mechanisms of action
  • Products:  Rapidly developing and commercializing Synthetic Biotics that transform the LIVES of patients and their families
  • Promise:  Building our company to launch multiple novel LIVING medicines mastering a new frontier in medicine
 We combine Human Logic and Science Logic to drive meaningful work, careers, and LIFE at Synlogic. We foster a people-focused environment grounded in:  Compassion, Transparency, Collaboration & Fun, while adopting a patient-focused mindset to inspire:  Innovation, Integrity, High Performance, and LIFE Changing Results.
 
We continue to build and enhance our organization. If you want a settled environment, pursuing a well-walked path then this environment is probably not for you.  If you want to join a growing company, work hard, and challenge yourself to find solutions at a new frontier of medicines then we would love to hear from you. 
 
POSITION SUMMARY:
 
We are seeking a highly motivated and enthusiastic scientist to drive development of microbial fermentation processes for manufacturing of the synthetic biotics. Reporting to the Head of Bioprocess Development, this individual will lead a team responsible for development of robust and scalable microbial fermentation processes for late-phase clinical manufacturing. 
 
Primary responsibilities include:
  • Lead and contribute to lab operations to support microbial fermentation process development, improvement, and validation
  • Identify technical strategies and design scale-down studies to provide a data-driven approach to process optimization and resolution of process deviations
  • Manage phase III and commercial process development activities, including FMEA risk assessment, screening studies, design of experiments (DOE), and process characterization
  • Provide technical insight into experimental design and perform data analysis using analytical tools such as JMP, MiniTab or Spotfire
  • Provide support for tech transfer, process characterization, process validation and manufacturing campaigns
  • Contribute to preparation of reports and documents required for regulatory submission
  • Represent the bioprocess development group through oral and written communication within the organization and to external organizations
Qualifications and experiences:
  • Degree in Chemical/Biological Engineering, Microbiology, Biotechnology or relevant scientific or engineering field; MS with 10+ years, PhD with 5+ years of relevant experience
  • Previous successful technology transfer and experience in bioprocess engineering and/or commercial manufacturing
  • Experience in Phase III or commercial PD of a biologic (protein/antibody/enzyme or a Live biotherapeutic product) desirable
  • Experience working with perfusion bioreactors (ATF or TFF) for high cell density cultures desirable
  • Familiarity and hands-on experience with analytical methods typically used in the manufacture and characterization of cell-based products
  • Knowledge of downstream unit operations (centrifugation, tangential flow filtration, and various chromatography systems)
  • Prior experience with leading projects and mentoring technical staff
  • Must have strong verbal and written communication skills
  • Must be flexible and able to work well within a fast-paced, dynamic and team-oriented environment
To learn more about us, visit www.synlogictx.com

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