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Senior Scientist, Sample Preparation

Boston, MA
Senior Scientist, Sample Preparation
Sherlock Biosciences, an exciting new diagnostic company based on next-generation CRISPR and Synthetic Biology technology platforms. We are creating a new generation of biology-based molecular diagnostics that can rapidly deliver accurate and inexpensive results in any setting. Our goal is to address unmet diagnostic testing needs in infectious disease, oncology, agriculture and other areas to transform public health. Successful candidates will join an exciting, collaborative and fast-paced company focused on improving human health worldwide.

This role will be responsible for developing technologies that enable Sherlock’s platforms to accurately diagnose the presence of nucleic acid target in a variety of sample matrices. Successful candidates will provide molecular diagnostic assay expertise and experience with sample preparation in an IVD environment. This role provides strategic and technical leadership in defining and achieving assay and product development objectives while ensuring compliance with health authority requirements. The Senior Scientist will contribute to partnering activities with life cycle teams and internal as well as external business partners to drive innovation and product development. This role will drive continuous improvement within product development processes and manage resources to achieve business results within budget. Successful candidates will join an exciting and fast-paced team focused on improving human health worldwide through highly innovative Synthetic Biology-based platforms for molecular diagnostics.

Essential functions
Reasonable accommodations may be made to enable individuals with disabilities to perform these essential functions.
  • Develop reagents and methods for sample preparation that are compatible with Sherlock’s amplification and detection technologies
  • Integrate sample preparation technologies into point-of-care platforms and consumables
  • Independently plan, design, optimize and execute experiments
  • Contribute towards the development of new assays targeting pathogens of interest
  • Conduct feasibility studies 
  • Develop reagents within design control process and manage validations 
  • Oversee critical reagent development, validation, and transfer to Operations
  • Provide data summaries, written reports and oral presentations to internal and external teams
  •  Work as part of a multi-disciplinary team with other scientists, chemists, engineers and manufacturing personnel
  • Inventive, with ability to implement ideas in the laboratory
  • Excellent analytical and troubleshooting capabilities
  • Technical proficiency in biochemistry and molecular biology techniques 
  • Perform high level analysis of experimental results
  • Demonstrated ability to lead complex projects with minimal supervision
  • Excellent written and verbal communication skills
  • Self-motivated, enthusiastic team player with a positive attitude
  • Commitment to achieving goals and adhering to timelines
Supervisory responsibilities
  • None
Work environment
  • Laboratory
Physical demands
  • Long periods of standing or sitting
Travel required
  • None
Required education and experience
  • Ph.D. in Bioengineering or Life Sciences with a minimum of 5 years of industry experience, or M.S. in Bioengineering or Life Sciences with minimum of 8 years industry experience
  • Demonstrated record of accomplishments (e.g., published papers and issued patents)
  • Direct experience in an IVD company
  • Experience extracting cells, virus, or nucleic acid from a variety of clinical matrices
  • Experience integrating sample preparation or molecular assays into IVD consumables
  • Demonstrated accomplishments in assay development under design controls
  • Demonstrated knowledge of cell and molecular biology, pathology, histology, or biochemistry with technical aptitude to learn different scientific applications quickly
  • Excellent leadership and communication skills, creative problem solver in technical area
Preferred education and experience
  • Extensive experience in IVD product development, preferably point of care
  • Experience with isothermal nucleic acid amplification technologies
  • Strong background in assay development, including nucleic acid manipulation and detection and/or immunoassays
  • Experience with 510k submissions 
  • Management of external collaborators
  • Project management experiences a plus
Additional eligibility requirements
  • None
Work authorization/security clearance requirements
Authorized to work in the United States
Affirmative Action/EEO statement
Diversity, Equity, and Inclusion are not merely trendy buzz words to us; they are part of our core values. We are committed to creating a community of well-rounded professionals from all ethnicities, nationalities, educational backgrounds, and genders. This “melting pot” of differences is what fosters ideas and innovations. Our beliefs span beyond our walls and into the world, as reflected in outreach to various underserved domestic and global communities.

Other duties
Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.
The ideal candidate will be prepared to BE GREAT!

Boldness - We will push boundaries and confidently confront any challenge.
Excellence - We will be our best and help our team members be their best.

Growth  - We will support each other to advance our careers and achieve our personal goals.
Respect - We care about ourselves and each other, behaving honestly and with integrity.
Equity - We will build a diverse and inclusive team which treats each other as we expect to be treated.
Accountability - We expect the team and hold each other responsible to meet our obligations.
Trust  - We will be open in our communications and support anyone acting on our core values.

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