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Scientist/Senior Scientist, Phage Display

Cambridge, MA

Company Overview

We are a pioneering, stealth-stage biotechnology company seeking to create enzymatic solutions to unmet challenges in medicine. Our proprietary evolution platform, developed in the lab of Prof. David Liu, enables us to rapidly generate novel proteases with high specificity and potency for user-defined therapeutic targets. By reprogramming the specificity of proteases, we aim to revolutionize the treatment of protein-driven diseases. World class scientific founders David Liu (Broad, Harvard), Min Dong (Boston Children’s Hospital, Harvard), Jim Wells (UCSF), and Travis Blum (Broad, Harvard) and backing from leading life science venture capital firms including Arch, Atlas, F-Prime, GV, and Newpath, come together in a dynamic start-up environment.

Job Summary

The Scientist – Phage Display will be responsible for implementing methods for protease characterization using display technologies to characterize human proteases with novel unprecedented specificity and selectivity. This will include performing and analyzing protease substrate display enrichment experiments, as well as developing new display capabilities to support ongoing candidate development and protein evolution programs. This position will require close collaboration between research teams to guide therapeutic development decisions.

Job Responsibilities

  • Serve as scientific lead for biochemical assessment and specificity profiling initiatives, including the design, execution, and cataloging of assay data
  • Develop and optimize new display and protease profiling workflows
  • Work collaboratively with additional evolutionary scientists, biochemists, and downstream characterization efforts to facilitate lead optimization of evolution outputs
  • Generate novel assays where necessary to support ongoing therapeutic development efforts
  • Generate data in a timely manner; lead/ co-lead discovery projects; contribute/present at project meetings

Required Skills & Qualifications

  • A Ph.D. in Biochemistry, Bioengineering, Chemical Biology or related field, with at least 2+ years of laboratory experience in an academic or industry setting; or a Masters’ degree with a minimum of 5 years of laboratory experience
  • Demonstrated experience in phage display or similar technologies, including library creation, selection, and enrichment analysis
  • Experience with substrate display methods or related protease characterization is preferred
  • Highly adaptable, strong problem solver, with the ability to innovate and work collaboratively
  • Impeccable verbal and written communications skills
  • Highly organized, exceptional attention to detail, and strong proficiency in documentation and presentation of data
  • Possesses an eager, proactive and collaborative approach to each day; must be a self-starter and persistent in achieving objectives to support our scientific and business goals

Additional requirements

In-person work is necessary for this position. We work in facilities that require all individuals working on-site to be fully vaccinated against COVID-19.

We recognize the value of diversity in our workforce and are committed to equal opportunity. We consider all qualified employment applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law. Individuals who hold legal work authorization applicable to employment in the United States will be considered without regard to citizenship/alienage.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.

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