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Senior/Principal Scientist, Protein Science

Cambridge, MA

Senior/Principal Scientist, Protein Production
Resonance Medicine

Company Overview
We are a pioneering, stealth-stage biotechnology company seeking to create enzymatic solutions to unmet challenges in medicine. Our proprietary protein evolution platform, developed in the lab of Prof. David Liu, enables us to rapidly generate novel proteases with high specificity and potency for user-defined therapeutic targets. By reprogramming the specificity of proteases, we aim to revolutionize the treatment of protein-driven diseases. World class scientific founders David Liu (Broad, Harvard), Min Dong (Boston Children’s Hospital, Harvard), Jim Wells (UCSF), and Travis Blum (Broad, Harvard) and backing from leading life science venture capital firms including Atlas, Arch, F-Prime, GV, and Newpath, come together in a dynamic start-up environment.

Job Summary
The Senior/Principal Scientist – Protein Production will be responsible for design of constructs, expression, purification, and QC of our novel protease therapeutics and associated reagents from microbial or mammalian cell culture. This includes design and optimization of expression constructs, expression and purification of proteins from pilot to scale-up, and QC including analytical SEC, SDS-PAGE, endotoxin assessment, and other properties as needed.  Purification strategies may include size exclusion, affinity, ion-exchange, and other chromatography techniques using an AKTA FPLC system or other methods.


Job Responsibilities

  • Execute protein production from construct design through expression, purification, and QC
  • Manage junior team members supporting the protein production pipeline
  • Work across team to maintain cells and reagents for protein production group
  • Work collaboratively with teams within Research groups to prioritize efforts
  • Generate data in a timely manner; lead discovery sub-teams; contribute/present at project meetings
  • Assume additional responsibilities as needed

Required Skills & Qualifications
 
  • A PhD in Biochemistry, Biochemical Engineering, Chemistry or related field with at least four years of post-graduate experience or a BS/MS with at least eight years of relevant experience
  • Experience with protein expression, primarily in bacterial systems, but also mammalian cells
  • Strong track record of experience with protein purification using AKTA/FPLC-based chromatography and QC
  • Highly adaptable, with the ability to innovate and work both independently and collaboratively
  • Strong problem-solving abilities
  • Ability to prioritize and deliver on tight timelines
  • Impeccable verbal and written communications skills
  • Highly organized, exceptional attention to detail, and strong proficiency in documentation skills
  • Possesses an eager, proactive and collaborative approach to each day; must be a self-starter and persistent in achieving objectives to support our scientific and business goals

Additional requirements
  • In-person work is necessary for this position. We work in facilities that require all individuals working on-site to be fully vaccinated against COVID-19.

We recognize the value of diversity in our workforce and are committed to equal opportunity. We consider all qualified employment applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law. Individuals who hold legal work authorization applicable to employment in the United States will be considered without regard to citizenship/alienage.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities.

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