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Fermentation Scientist

Cambridge, MA
About Vedanta Biosciences, Inc.

Vedanta is pioneering the development of a new class of therapies that act by modulating the human microbiome. Modulation of the human microbiota holds enormous promise to treat a broad range of immune and infectious diseases in ways that are completely different to existing drug classes. Breakthrough discoveries of our scientific team in the field of mucosal immunology have led to the first rationally designed drug candidates in the microbiome field. Vedanta was founded by PureTech Health and a team of world-renowned experts in immunology and microbiology. 

We invite you to explore our site to learn more about our company and how our discovery platform enables the identification of bacterial consortia with drug-like properties and their manufacture to GMP standards.

About Us, About You
 

At Vedanta, we value diversity in all its forms and are looking for candidates with a wide variety of perspectives, backgrounds, education, and experiences. We believe that a diverse and inclusive workforce builds the strongest team possible.

We're proud of our workplace culture. Our Vedanta Values inspire us to be the best professionals and colleagues possible. Our values are:
Respect - Collaboration - Execution - Effective Communication - Problem Solving - Scientific Thoroughness

About the role

Vedanta is seeking a talented Fermentation Scientist to join the Process Development group. The scientist will support ongoing early- and late-stage process development efforts for stabilization and production of Vedanta Biosciences’ portfolio of Live Biotherapeutic Products (LBPs). Vedanta is developing defined bacterial consortia LBPs to treat intestinal pathogen infections, cancer, allergy, and inflammatory bowel diseases. The candidate will be responsible for driving the development of microbial fermentation processes at bench and pilot scales for transfer to cGMP manufacturing. We are looking for an individual who is independent, curious, self-motivated, excited to collaborate, and an excellent communicator.

Here’s What You’ll Do:
  • Work closely with the discovery team to map the characteristics of Vedanta’s live biotherapeutic products and develop processes to manufacture them at scale. 
  • Design and execute experiments with team to optimize media and fermentation conditions for a variety of anaerobic bacteria. Utilize a variety of data types to improve understanding and drive development of processes.
  • Collaborate with downstream process development engineers to identify harvest conditions to maximize viability and stability of live biotherapeutic products.
  • Be responsible for running the Process Development laboratory on a day-to-day basis, including being responsible for maintaining adequate supplies, equipment selection and maintenance, and liaising with suppliers of process development equipment.
  • Write technical reports to transfer processes to CGMP manufacturing.
  • Liaise with Quality Assurance and Control to ensure CGMP compliance.

Requirements:

  • PhD in Chemical Engineering, Bioengineering, Microbiology, or related field; or MS degree in similar field and 4-6 years of relevant experience in the pharmaceutical or biotech industry or in a Contract Manufacturing Organization
  • Experience fermentation development and characterization
  • Experience working with anaerobes is highly preferred
  • Experience working with TFF and lyophilization of microbes is a plus
  • Previous experience running bench-scale fermentation (1 – 10L)
  • Entrepreneurial and self-motivated work style

Vedanta is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Vedanta will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Vedanta Biosciences requires all employees to be fully vaccinated against COVID-19 and newly hired employees must be fully vaccinated prior to their employment start date. Vedanta Biosciences will consider accommodations for individuals who are unable to be vaccinated against COVID-19 due to a qualifying medical condition or disability or a sincerely held religious objection.

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