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Senior Research Associate, Formulation

Cambridge, MA · Science/Research

Company Overview:

Synlogic™ is bringing the transformative potential of synthetic biology to medicine. We are building the premier Synthetic Biology platform to engineer bacterial Synthetic Biotic medicines which benefit patients in new ways.

Using a platform that leverages reproducible, modular approach to microbial engineering, Synlogic designs Synthetic Biotic medicines that target validated underlying biology to treat disease in new ways.  

Synlogic’s proprietary pipeline includes Synthetic Biotics for the treatment of metabolic disorders,  including Phenylketonuria and Enteric Hyperoxaluria, and immunology.  

We combine Human Logic and Science Logic to drive meaningful work, careers, and life at Synlogic. We foster a people-focused environment grounded in: Compassion, Transparency, Collaboration & Fun, while adopting a patient-focused mindset to inspire: Innovation, Integrity, High Performance, and life-changing Results. 

We continue to build and enhance our organization. This position is best suited for professionals who are comfortable working in a growing and adaptable, biotech environment. 

If you want to challenge yourself and build your career while bringing the transformative potential of synthetic biology to patients then we’d love to hear from you. 

Position Summary: 

The Sr Associate of Formulation Development will support the development of drug substance and drug product at Synlogic. The individual will be responsible for performing unit operations related to drying of drug substance formulations for live biotherapeutic products and supporting development of solid oral dosage forms. Additionally, the individual will be responsible for performing analytical characterization to enable the development of the formulations.  

Key Accountabilities/duties:

As part of this effort, the person will be expected to: 

  • Execute studies for development of dried drug substance formulations of live biotherapeutics  and generation of analytical data to support formulation decisions 
  • Execute studies for development of solid oral dosage forms and analytical characterization of  these dosage forms  
  • Write and review technical protocols and reports documenting formulation studies and  analytical data  
  • Summarize and present results supporting formulation decisions

Qualifications & Experiences:

BS or MS in chemical engineering, biomedical engineering, pharmaceutical sciences or related field with  2+ years of relevant industry experience.
The applicant must have demonstrated experience with some of the following: 

  • Experience with drying approaches such as freeze drying, spray drying, or fluid bed drying 
  • Experience with solid dosage form unit operations such as capsule filling, tableting, granulation,  and coating 
  • Experience with designing and executing dissolution studies for characterization of solid oral  dosage forms 
  • Experience with live biotherapeutics and microbiological assays is a plus 
The applicant must have the following skills: 
  • Ability to quickly learn and perform unit operations and analytical methods 
  • Ability to operate independently in a laboratory setting 
  • Detail oriented in recording and analysis of data 
  • Confident oral and written communication skills.  
  • Demonstrated ability to multitask work to support different projects and the ability to adapt to  changing timelines and priorities 


Our 6 values of Compassion, Fun, Trust & Respect, Innovation, Integrity and Results are central to our organization.  

Synlogic is committed to creating a diverse and inclusive environment and is proud to be an equal opportunity employer, embracing diversity in all forms. Synlogic hires, trains, compensates and promotes talented Synlogicians regardless of age, color, disability, gender, gender identity or expression, genetics,  national origin, race, religion, sexual orientation, veteran status, and other protected statuses as required by the laws and cultures of the geographies in which we operate. We believe in lifting others both inside and outside of the company, ensuring all of our community has access to opportunities and innovative therapies. 

Our compassion for patients is the engine that drives our innovation and motivates our sense of urgency;  always remembering that patients are waiting. Our compassion for each other creates a safe environment for continuous risk-taking and personal development – facilitating a rapidly moving, fast-paced environment. We connect with our colleagues by having fun together.  
We take our work seriously and value integrity in producing the highest quality work. We trust each other,  respecting all ideas and driving accountability to generate the best results for our patients and team. We encourage openness, direct feedback, and transparency in decision-making to enable an inclusive, nimble environment. 

We seek individuals who exemplify these behaviors and who encourage others to do the same.

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