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Principal Associate Scientist, In Vivo Immunology

Boston, MA

About GentiBio 

GentiBio is an emerging biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology from Seattle Children’s Research Institute, Benaroya Research Institute, and MIGAL Galilee Research Institute. GentiBio is focused on the development of EngTregs programmed to treat autoimmune, alloimmune, autoinflammatory and allergic diseases. GentiBio’s proprietary autologous and allogeneic EngTregs platform integrates key complementary technologies needed to successfully restore immune tolerance and overcome major limitations in existing regulatory T-cell therapeutics.   

GentiBio is seeking to build an organization with an exceptional company culture focused on empowerment, care for our team members, an appreciation for diversity and inclusion, and the development of our people. As such, we are looking for candidates who are not just great scientists and business professionals, but individuals who are looking to contribute to building and modeling an outstanding company culture – and having fun while doing so.   

GentiBio is building corporate operations in both Boston and Seattle. We are looking for outstanding leaders and scientists to join our team in both of our locations. 

Job Summary 

GentiBio is seeking a collaborative, creative, and results-oriented Principal Associate Scientist to join our Discovery team in Boston. The successful candidate will conduct in vivo proof-of-concept (PoC), validation, and pharmacology studies to support multiple pre-clinical programs. We are searching for an enthusiastic individual who is passionate about in vivo discovery and solving complex problems. This role offers exposure to various facets of an organizational and company build, leadership and technological growth, and an ample opportunity to be a high-impact trailblazer in the emerging field of regulatory T-cell therapy. 

Job Responsibilities 

  • Foster the culture of seeking and giving help, inclusion, authenticity, and fun 
  • Independently design and plan in vivo studies to support early discovery to pre-clinical development efforts 
  • Execute efficacy and mode of action (MoA) studies using various rodent autoimmune models 
  • Perform intravenous and intraperitoneal injections and collect and process tissue samples (e.g., blood, spleen, lymph node) for ex vivo studies  
  • Profile immune cells by multicolor flow cytometry and conduct cytokine and antibody analyses by ELISA or flow-based techniques (e.g., CBA) 
  • Assist with vivarium operations and perform routine measurements and health monitoring 
  • Ensure data collection is captured in electronic laboratory notebooks and databases 
  • Perform data analysis, summarize results in study reports, and provide regular updates at internal meetings 
  • Mentor and train junior scientists 

Qualifications and Education Requirements 

  • BS in biological sciences or related area with 8+ years or MS with 5 years of research experience working in animal models of autoimmunity, inflammation and/or cancer within biotechnology, pharmaceutical, CRO, or academic environments 
  • Proficiency in IV and IP administration required, experience with intranasal injection or tracheal inoculation desired 
  • Experience isolating cells from mucosal tissue, cell culture, and in vitro assays strongly desired 
  • Familiarity with cellular therapeutics preferred but not required 
  • Proficiency in Excel, PowerPoint, GraphPad Prism, and ELN/LIMS for data entry, analysis, and presentation 
  • Strong attention to detail and demonstrated ability to execute experiments with rigor and maintain clear and complete records of lab work 
  • Exceptional teamwork and communication skills with the ability to embrace change and multitask in a fast-growing environment 
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