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Senior Associate Scientist, Cellular Immunology

Boston, MA

About GentiBio 

GentiBio is an emerging biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology from Seattle Children’s Research Institute, Benaroya Research Institute, and MIGAL Galilee Research Institute. GentiBio is focused on the development of EngTregs programmed to treat autoimmune, alloimmune, autoinflammatory and allergic diseases. GentiBio’s proprietary autologous and allogeneic EngTregs platform integrates key complementary technologies needed to successfully restore immune tolerance and overcome major limitations in existing regulatory T-cell therapeutics. 

GentiBio is seeking to build an organization with an exceptional company culture focused on empowerment, care for our team members, an appreciation for diversity and inclusion, and the development of our people. As such, we are looking for candidates who are not just great scientists and business professionals, but individuals who are looking to contribute to building and modeling an outstanding company culture – and having fun while doing so. 

GentiBio is building corporate operations in both Boston and Seattle. We are looking for outstanding leaders and scientists to join our team in both of our locations. 

Job Summary 

GentiBio is seeking collaborative and motivated Senior Associate Scientists to join our Discovery team in Boston. The successful candidates will design and execute in vitro and ex vivo studies to characterize EngTregs to support our preclinical programs. We are searching for enthusiastic individuals who are passionate about working at the bench to advance programs and solve complex challenges. This role offers exposure to an organizational and company build, leadership, and an ample opportunity to be a high-impact trailblazer in the emerging field of regulatory T-cell therapy. 

Job Responsibilities 

  • Foster the culture of seeking and giving help, inclusion, authenticity, and fun 
  • Plan and execute in vitro and ex vivo experiments to investigate functional features of Treg cell prototypes 
  • Isolate and culture primary immune cells from PBMCs or human/mouse tissues for downstream analysis 
  • Perform functional and phenotypic characterization of T-cells, including proliferation, differentiation, suppression, and MLR assays 
  • Analyze T-cell phenotype and function by multicolor flow cytometry, ELISA, and gene expression analysis 
  • Ensure data collection is captured in electronic laboratory notebooks and databases 
  • Perform data analysis, summarize results in study reports, and provide regular updates at internal meetings 

Qualifications and Education Requirements 

  • BS in cell biology, immunology or related field and 5+ years of relevant industry experience OR
  • MS in relevant field with 2+ years of industry experience 
  • Hands-on experience with primary mouse or human cell culture 
  • Experience with current immunology techniques such as multicolor flow cytometry, ELISA, PCR, and cell-based assays 
  • Familiarity with gene editing and delivery technologies (e.g., CRISPR and viral transduction) preferred 
  • Proficiency in Excel, PowerPoint, GraphPad Prism, and ELN/LIMS for data entry, analysis, and presentation 
  • Strong attention to detail and demonstrated ability to execute experiments with rigor and maintain clear and complete records of lab work 
  • Exceptional teamwork and communication skills with the ability to embrace change and multitask in a fast-growing environment 
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