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Scientist/Senior Scientist, In Vivo Immunology

Boston, MA

About GentiBio 

GentiBio is an emerging biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology from Seattle Children’s Research Institute, Benaroya Research Institute, and MIGAL Galilee Research Institute. GentiBio is focused on the development of EngTregs programmed to treat autoimmune, alloimmune, autoinflammatory and allergic diseases. GentiBio’s proprietary autologous and allogeneic EngTregs platform integrates key complementary technologies needed to successfully restore immune tolerance and overcome major limitations in existing regulatory T-cell therapeutics. 

GentiBio is seeking to build an organization with an exceptional company culture focused on empowerment, care for our team members, an appreciation for diversity and inclusion, and the development of our people. As such, we are looking for candidates who are not just great scientists and business professionals, but individuals who are looking to contribute to building and modeling an outstanding company culture – and having fun while doing so. 

GentiBio is building corporate operations in both Boston and Seattle. We are looking for outstanding leaders and scientists to join our team in both of our locations. 

Job Summary 

GentiBio is seeking motivated and talented Scientists and Senior Scientists to join our Discovery team in Boston. These roles will play an integral part in advancing our preclinical programs for Type I Diabetes and undisclosed indications. The successful candidates will design and execute in vivo preclinical efficacy studies and downstream ex vivo cellular and molecular mechanistic investigations. The ideal candidates will be enthusiastic and are passionate about in vivo discovery and solving complex problems. This role offers exposure to an organizational and company build, leadership, and an ample opportunity to be a high-impact trailblazer in the emerging field of regulatory T-cell therapy. 

Job Responsibilities 

  • Foster the culture of seeking and giving help, inclusion, authenticity, and fun 
  • Lead the design and execution of in vivo Proof-of-Concept (PoC) experiments to investigate therapeutic efficacy and underlying mode of action (MoA) 
  • Design and oversee the development of cell-based assays and molecular tools to support project advancement 
  • Perform functional and phenotypic characterization of T-cells, including proliferation, differentiation, suppression, and MLR assays 
  • Analyze T-cell phenotype and function by multicolor flow cytometry, ELISA, and gene expression analysis 
  • Stay abreast of relevant literature and act as a resource for the team 
  • Contribute proactively to cross-functional activities across research groups and with other departments as needed 
  • Communicate and present scientific findings to scientific team and management 
  • Mentor and train junior scientists 

Qualifications and Education Requirements 

  • PhD in immunology, cell biology, or related field with 1+ years or MS with 7+ years of relevant experience 
  • Background in T cell biology required, regulatory T cells preferred 
  • Demonstrated experience designing mouse studies to assess cellular function required 
  • Experience isolating and culturing primary immune cells from PBMCs or human/mouse tissues required 
  • Hands-on experience with current immunology techniques such as multicolor flow cytometry, ELISA, PCR, and cell-based assays required 
  • Familiarity with gene editing and delivery technologies (e.g., CRISPR and viral transduction) preferred 
  • Experience mentoring and managing direct reports preferred  
  • Exceptional teamwork and communication skills 
  • Flexibility to pivot from plan A to plan B and ability to synthesize complex information and focus on key deliverables 
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