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Director, Information Technology

Cambridge, MA

About Theseus

Theseus Pharmaceuticals is passionately committed to improving the lives of cancer patients by working to outsmart cancer resistance. Led by a team of targeted oncology pioneers with a proven track record developing and commercializing cancer therapeutics, we are developing the next generation of tyrosine kinase inhibitors (TKIs): “pan-variant” targeted therapies that address all known drug resistant mutations. We believe a pan-variant approach is the only way to address cancer resistance. Our lead program, THE-630, is a pan-variant KIT inhibitor for patients with advanced gastrointestinal stromal tumors (GIST), whose cancer has developed resistance to earlier lines of kinase inhibitor therapy. We are also developing a fourth-generation, selective epidermal growth factor receptor (EGFR) inhibitor to address C797S-mediated resistance to first- or later-line osimertinib treatment in patients with non-small cell lung cancer (NSCLC). For more information, visit theseusrx.com or follow the company on LinkedIn.

Role Description

The Director of Information Technology (“IT”) will report to the CFO, and will own and drive the long-term strategy for the Theseus IT systems with an emphasis on security, productivity, and scalability. This position will manage and build Theseus’ IT capabilities and act as a trusted advisor to the business to proactively identify technology needs and implement effective solutions. The Director of IT will be responsible for all aspects of corporate IT infrastructure, networking, and data security and must have a proven track record of building relationships formed upon trust, credibility, and impact in support of a rapidly growing and integrated biotechnology company.


  • Define and implement the Theseus IT strategic roadmap working closely with business leaders to identify present and future IT needs
  • Understand the organization's goals, objectives, and strategic direction to identify opportunities for technology solutions across various departments. Partner with business to define the requirements for new solutions and ensure solutions implementation meet the business needs including comprehensive deployment support, training, user support, and metrics to evaluate value delivery
  • Establish and build relationships with vendors, including evaluating vendor capacity and security and leading negotiations relating to all IT needs. Manage external help desk and external IT vendors and ensure that end users receive optimal support to maximize their productivity
  • Oversee and enforce IT policies, procedures and associated plans for security, data center, and infrastructure based on industry-standard best practices as well as SOX, HIPAA, GDPR, PHI, FDA, and privacy requirements
  • Own and manage the IT infrastructure build-out of our new corporate headquarters
  • Plan and ensure implementation for updates and maintenance of all IT infrastructure needs with minimal impact on end users
  • Oversee security of systems, networks, and enterprise information. Complete regular cyber security assessments and IT security audits and investigations. Define gaps, identify solutions, and implement, as needed.
  • Oversee purchasing of hardware and software products and management of software and support licenses.
  • Prepare and manage detailed IT budgets and resource plans to enable the company to meet its short-term and long-term goals


  • BS in Computer Science or related field required with a minimum of seven years of hands-on IT leadership and business partner experience, preferably within the Biotech/Pharma industry
  • Experience managing and implementing IT solutions in a start-up public biotech environment
  • Experience building and scaling IT infrastructure to support a small company in high growth mode
  • Comprehensive knowledge of essential IT functions including network infrastructure, storage, servers, databases, cloud computing, ERP, disaster recovery, security, telecommunications, and vendor management
  • Experience leading IT teams consisting of onsite resources, contractors, consultants, and managed services providers
  • End-to-end solutions implementation experience, including identification, deployment, roll-out, training, and user support
  • Experience migrating/upgrading technologies enterprise-wide
  • A proactive partner with the demonstrated ability to confidently engage with key stakeholders to gain an understanding of the business' evolving IT needs, develop and recommend innovative and cost-effective solutions
  • Ability to identify and deploy solutions to enhance the effectiveness of a complex, scientific, data-driven organization
  • Superior organizational, planning, and project management skills
  • Strong written and oral communication skills
  • Demonstrated strong leadership and written/verbal communication skills
  • Collaborative work style in a hands-on team-oriented environment
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