Theseus Pharmaceuticals is passionately committed to improving the lives of cancer patients by working to outsmart cancer resistance. Led by a team of targeted oncology pioneers with a proven track record developing and commercializing cancer therapeutics, we are developing the next generation of tyrosine kinase inhibitors (TKIs): “pan-variant” targeted therapies that address all known drug resistant mutations. We believe a pan-variant approach is the only way to address cancer resistance. Our lead program, THE-630, is a pan-variant KIT inhibitor for patients with advanced gastrointestinal stromal tumors (GIST), whose cancer has developed resistance to earlier lines of kinase inhibitor therapy. We are also developing a fourth-generation, selective epidermal growth factor receptor (EGFR) inhibitor to address C797S-mediated resistance to first- or later-line osimertinib treatment in patients with non-small cell lung cancer (NSCLC). For more information, visit theseusrx.com or follow the company on LinkedIn.
We are seeking a Principal Scientist/Associate Director, Medicinal Chemistry to join our passionate team of scientists. The ideal candidate should be a highly motivated, experienced, and creative medicinal chemist with a proven track record of success in drug discovery from early Lead Generation through late-stage Lead Optimization. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based, and fast paced setting. This role will report to the Vice President of chemistry.