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Bioanalytical Scientist

Cambridge, MA · Science/Research

Synlogic™ is bringing the transformative potential of synthetic biology to medicine. We are building the premier Synthetic Biology platform to engineer bacterial Synthetic Biotic medicines to benefit patients in new ways.  

Using a platform that leverages reproducible, modular approaches to microbial engineering, Synlogic designs Synthetic Biotic medicines that target validated underlying biology to treat disease.  

Synlogic’s proprietary pipeline includes Synthetic Biotics for the treatment of metabolic disorders including phenylketonuria and enteric hyperoxaluria. The company is also building a portfolio of assets in immunology and oncology.  

We combine Human Logic and Science Logic to drive meaningful work, careers, and life at Synlogic. We foster a people-focused environment grounded in: Compassion, Transparency, Collaboration & Fun, while adopting a patient-focused mindset to inspire: Innovation, Integrity, High Performance, and life-changing Results.  

We continue to build and enhance our organization. If you want to challenge yourself and build your career while bringing the transformative potential of synthetic biology to patients then we’d love to hear from you.  

Position Summary: 

Synlogic is seeking a Bioanalytical Scientist who will develop and implement bioanalytical assays to characterize engineered bacterial strains. The ideal candidate will support the metabolic and immunology disease area program teams from discovery through early clinical development. The scientist will also play a key role in discovering translational biomarkers of disease biology and engineered therapeutic strain function in vivo. This role is in our Translational Science group. It represents an opportunity to make a substantial impact on advancing our Synthetic Biotic pipeline. 

Key Responsibilities: 

  • Represent the bioanalytical function on disease area program teams to advance research projects through key development milestones 
  • Develop and optimize bioanalytical assays for small molecule metabolites and protein/peptide biomarkers in various biological matrices 
  • Define in vivo biomarkers of engineered strain function and/or disease biology using targeted and untargeted metabolomics/proteomics approaches 
  • Routinely generate and analyze data using quantitative LC-MS/MS and immunoassay techniques 
  • Generate data reports, maintain a detailed electronic laboratory notebook, communicate results with other scientists, and provide data presentations 
  • Maintain analytical instrumentation and troubleshoot issues as needed 
  • Expected to spend at least 75% of the time in the laboratory 

Education and Skills Requirements: 

  • PhD in Chemistry, Analytical Chemistry, Biochemistry, or a related field 
  • Experience in small quantitative molecule LC-MS/MS analysis required 
  • Experience operating, troubleshooting, and maintaining LC-MS/MS and related analytical equipment 
  • Strong attention to detail and accuracy with an ability to work independently to solve technical problems 
  • Experience with immunoassays, such as ELISA, AlphaLISA, or TR-FRET, preferred 
  • Highly organized with excellent written and oral communication skills   
  • Knowledge of FDA guidance for bioanalytical method qualification a plus 

Behaviors: 

We are at our best when we combine Human Logic and Science Logic to build great teams and deliver outstanding results. Our 6 values of Compassion, Fun, Trust & Respect, Innovation, Integrity and Results are central to our organization. 

Synlogic is committed to creating a diverse and inclusive environment and is proud to be an equal opportunity employer, embracing diversity in all forms. Synlogic hires, trains, compensates, and promotes talented Synlogicians regardless of age, color, disability, gender, gender identity or expression, genetics, national origin, race, religion, sexual orientation, veteran status, and other protected statuses as required by the laws and cultures of the geographies in which we operate. We believe in lifting others both inside and outside of the company, ensuring all of our community has access to opportunities and innovative therapies.

Our compassion for patients is the engine that drives our innovation and motivates our sense of urgency; always remembering that patients are waiting. Our compassion for each other creates a safe environment for continuous risk taking and personal development – facilitating a rapidly moving, fast-paced environment. We connect with our colleagues by having fun together. 

We take our work seriously and value integrity in producing the highest quality work. We trust each other, respecting all ideas and driving accountability to generate the best results for our patients and team. We encourage openness, direct feedback, and transparency in decision-making to enable an inclusive, nimble environment. 

We seek individuals who exemplify these behaviors and who encourage others to do the same.  

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