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Scientist, Discovery

Needham, MA

Candel Therapeutics is a clinical-stage biotechnology company pioneering the development of viral based immunotherapies for the treatment of solid tumors. Candel’s products are designed to significantly help patients fight their cancer while maintaining quality of life – from early - to late-stage disease. Join our rapidly growing company where you will wear multiple hats in an environment that values innovation, scientific rigor and a “can do” attitude. We care about our team, our patients, and our community. We have a robust pipeline with clinical assets in phase 1, 2 and 3 for the treatment of prostate, brain, lung and pancreatic cancers   Please visit www.Candeltx.com for additional information.  


The Discovery group is seeking a highly motivated, collaborative scientist to join a team focused on building Candel Therapeutics’ next-generation oncolytic viral immunotherapy platform. Reporting to the Director of Early Research, this Scientist will play a critical role, supporting the implementation of a novel discovery workflow designed to achieve rapid proof-of-efficacy and streamlined development of new HSV-1 oncolytic virus candidates. 


  • Establish robust cell-based assays pertinent to tumor immunology to support internal discovery platform  
  • Design, plan, and independently perform a variety of in vitro and ex vivo immune cell-based assays to test novel oncolytic viral vectors  
  • Design complex flow cytometry panels and perform flow analysis on immune and cancer cells 
  • Document and organize experimental procedures and results; generate experimental reports   
  • Synthesize and integrate results across experiments and present to colleagues and senior management  
  • Work cross-functionally with internal key stakeholders including Vectorology and Experimental Medicine 
  • Facilitate interactions with external partners and CROs to advance discovery programs 
  • Contribute to a dynamic, fast-paced scientific culture that embraces creativity and innovation 


  • A Ph.D. in Immunology or Immuno-Oncology  
  • Experience in cell culture (both primary cells and established cell lines) and execution of a variety of in vitro/ex vivo immune cell-based assays 
  • Expertise in assay development and troubleshooting for complex cell-based assays 
  • Extensive knowledge and hands-on experience with advanced flow cytometry including panel design and analysis 
  • Track record of high-quality, rigorous scientific work 
  • Excellent attention to detail, communication skills, and flexibility 
  • Knowledge of Microsoft Word, PowerPoint, FACSDiva, and GraphPad Prism is needed for the preparation of reports to management 
  • Previous experience with oncolytic viruses or gene therapies is a plus 
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