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Director/Senior Director, Program Management

Cambridge, MA

About Theseus
Theseus Pharmaceuticals is passionately committed to improving the lives of cancer patients by working to outsmart cancer resistance. Led by a team of targeted oncology pioneers with a proven track record developing and commercializing cancer therapeutics, we are developing the next generation of tyrosine kinase inhibitors (TKIs): “pan-variant” targeted therapies that address all known drug resistant mutations. We believe a pan-variant approach is the only way to address cancer resistance. Our lead program, THE-630, is a pan-variant KIT inhibitor for patients with advanced gastrointestinal stromal tumors (GIST), whose cancer has developed resistance to earlier lines of kinase inhibitor therapy. We are also developing a fourth-generation, selective epidermal growth factor receptor (EGFR) inhibitor to address C797S-mediated resistance to first- or later-line osimertinib treatment in patients with non-small cell lung cancer (NSCLC). For more information, visit theseusrx.com or follow the company on LinkedIn.

Role Description
We are looking for an experienced early-stage Director/Senior Director-level Program Manager to support the THE-630 program team, oncology experience preferred. This individual will report directly to the President of R&D. The incumbent for this role must be a creative, agile, grounded Program Manager, who is able to bring structure, process and order to the work. This role presents an opportunity to both “do” and “build” what is needed now and in the future.


  • Develop and guide program strategy, set program goals and facilitate team decision making for the program
  • Lead program management activities for the program, including all aspects of program operational planning and execution such as timeline and milestones tracking, Program Team meeting management/minutes, decision making support, portfolio management activities and internal reporting
  • Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency
  • Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans
  • Develop and manage the Program budget, and long-range plan, including scenario planning as needed
  • Facilitate strong cross-functional communication by building strong working relationships across the organization
  • Develop materials and present program updates/progress at internal company meetings
  • Help to shape the Program Management function and establish best practices


  • Demonstrated track record of success in industry with 8+ years of overall industry experience and 3-5+ years of program management experience in the biopharmaceutical industry required; advanced degree and/or PMP preferred
  • Experience in early-stage clinical drug development required
  • Experience in oncology drug development strongly preferred
  • Excellent verbal and written communication skills and demonstrated ability to manage by influence and problem solve in a highly matrixed organization
  • Prior success with managing cross-functional development teams in a hands-on, highly collaborative, fast paced growth environment
  • Ability to make recommendations to effectively resolve problems or issues, by using sound judgment that is consistent with business standards, practices, policies, procedures and regulations
  • Deep functional knowledge, coupled with business acumen, personal credibility, and outstanding leadership skills
  • Ability to think strategically and execute tactically
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