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Scientist-Principal Scientist, T-Cell Product Characterization

Seattle, WA

About GentiBio
GentiBio is an emerging biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology from Seattle Children’s Research Institute, Benaroya Research Institute, and MIGAL Galilee Research Institute. GentiBio is focused on the development of EngTregs programmed to treat autoimmune, alloimmune, autoinflammatory and allergic diseases. GentiBio’s proprietary autologous and allogeneic EngTregs platform integrates key complementary technologies needed to successfully restore immune tolerance and overcome major limitations in existing regulatory T-cell therapeutics.  

GentiBio is seeking to build an organization with an exceptional company culture focused on empowerment, care for our team members, an appreciation for diversity and inclusion, and the development of our people.  As such, we are looking for candidates who are not just great scientists but individuals who are looking to contribute to building and modeling an outstanding company culture – and having fun while doing so. 

GentiBio is building corporate operations in both Boston and Seattle. We are looking for outstanding leaders and scientists to join our team in both of our locations. 

Job Summary 

GentiBio is seeking a self-driven, collaborative, results-oriented and creative Scientist – Principal Scientist to join our Analytical Development (AD) team in Seattle in the role of a product characterization and cell-based assays lead in support of GentiBio’s first engineered regulatory T-cells (EngTregs) program. This role offers exposure to multiple facets of an organizational and company build, leadership and technical growth, and an ample opportunity to be a high impact trailblazer in the emerging field of regulatory T-cell therapy.  

Job Responsibilities  

  • Foster the culture of seeking and giving help, inclusion, authenticity, and fun 
  • Own the definition of EngTreg target drug product profile and product characterization strategy  
  • Develop cell-based drug product characterization methods 
  • Oversee characterization testing of development and clinical drug product lots and own the correlative analysis of the data against clinical outcomes 
  • Partner closely with Research, Translational, and Process Development teams to align on the key EngTreg product attributes and best approaches to measure them 
  • Communicate results to cross-functional teams 
  • Contribute content to regulatory filings  
  • Participate as a Treg biology expert in development or clinical investigations as needed 
  • Collaborate with the Research team and the academic collaborators to ensure relevant product knowledge transfer to and from Technical Development organization 
  • Contribute to the build of the cell therapy development laboratory from lab layout to mapping out of analytical workflows 
  • Opportunity to manage and mentor junior scientists 
  • Contribute technical expertise to new technology due diligence efforts as needed 

Qualifications and Education Requirements 

  • Ph.D. in Immunology, Cell Biology or equivalent discipline with at least two years of characterization experience of T-cell products 
  • Expertise in Treg biology and experience with development of T-cell characterization methods required 
  • Experience with statistical data analysis and mammalian gene editing systems preferred 
  • Experience with CMC regulatory filings preferred but not required 
  • Supervisory experience preferred but not required  
  • Exceptional teamwork and communication skills 
  • Flexibility to pivot from plan A to plan B 
  • Ability to synthesize complex information and focus on key deliverables  
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