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Scientist/Senior Scientist, AAV Cell Culture Process Development

Cambridge, MA · Science/Research

Company Summary:

Tessera Therapeutics is an early-stage life sciences company pioneering Gene Writing, a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Position Summary:

Tessera Therapeutics is seeking a motivated and creative Scientist/Senior Scientist to join a team of scientists and engineers focused on development of robust and scalable cell culture processes for manufacture of AAV viral vectors. The candidate will provide subject matter expertise for development, optimization, characterization, and scale-up of cell culture processes and tech transfer to the GMP facilities.

Key Responsibilities:

  • Lead development of scalable and productive cell culture processes for AAV manufacturing.
  • Design and execute the small-scale experimental plan for screening, optimization, and scale-up efforts for AAV production and interpret the results independently.
  • Perform cell culture experiments in shake-flasks, bench-scale bioreactors, and high throughput cell culture systems.
  • Troubleshoot lab workflows and maintain lab equipment.
  • Contribute to the development of in-house AAV production capabilities and to the supply of high quality AAV for pre-clinical and platform development.
  • Assist in development of in-house AAV production capabilities to supply of high quality AAV for pre-clinical and platform development.
  • Interact with external CMOs, vendors, and partners and assist in technology transfers to CMOs.
  • Collaborate effectively with purification and analytical development teams.
  • Draft protocols and technical reports and participate/present to stakeholders internally and externally.
  • Develop and qualify reliable scale down models.
  • Write protocols and technical reports and participate/present to cross-functional teams.

Basic Qualifications:

  • MS with 6-10 years or PhD with 0-4 years of relevant industrial experience.  Degree emphasis in Chemical Engineering, Bioengineering, or Biological Sciences.
  • Strong technical understanding and experience in upstream process development and manufacturing for viral vectors or biologics. A proven track record of AAV cell culture development is strongly preferred.
  • Experience with bioreactor operation and scale-up
  • Experience with high-throughput cell culture process development platforms and statistical design of experiments (DoE) is strongly preferred.
  • Experience with process development and Quality by Design (QbD) methodology.
  • Knowledge of GMP/ICH/FDA regulations for early-stage viral vector gene therapy programs is strongly preferred.
  • A strong self-starter, independent thinker, with a strong attention to details.
  • Track record of completing deliverables within specified timelines.
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
  • Eager to work with highly skilled and dynamic teams in a fast-paced, entrepreneurial, and technical setting.

 

More About Flagship Pioneering

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX).

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