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Research Associate/Senior Research Associate, Molecular Biology

Cambridge, MA · Science/Research
About Carmine Therapeutics
Carmine Therapeutics is an Esco Ventures X company pioneering a powerful new class of drugs based on engineered red blood cells extracellular vesicles (RBCEVs), founded by Esco Ventures and Professors Harvey Lodish, Minh Le, and Jiahai Shi. Carmine's proprietary Red Cell EV Gene Therapy (REGENT™) platform is positioned to address some of the unmet technological needs related to the delivery of next-generation therapeutic modalities such as nucleic acids. Carmine was awarded the 2019 Bristol-Myers Squibb's Golden Ticket to LabCentral (Cambridge, MA) and has established a research collaboration with Takeda Pharmaceuticals in a deal worth over $900M USD. The Company is well-capitalized to develop next-generation non-viral gene therapies to overcome most AAV-based gene therapy limitations. Carmine is based both in Cambridge, MA, and Singapore.

About the Role
The Biology Team is looking for a (Senior) Research Associate to join us in this exciting journey. An ideal candidate is one who is independent, motivated, technically competent, and able to work efficiently in a team.

Responsibilities
  • Support preparation of engineered red blood cell extracellular vesicles (RBCEVs)
  • Perform cell culture experiments to characterize RBCEVs
  • Perform molecular biology experiments to support the development of the platform
  • Analyze and interpret experimental data
  • Maintain accurate and detailed documentation including electronic lab notebook
  • General laboratory assistance including organizing lab supplies, preparation of reagents, and lab equipment maintenance
  • Present research findings in the internal meetings 

Required Qualifications & Experience
  • B.S. in Biology, Immunology, Biochemistry or related discipline with prior laboratory research experience, or;
  • M.S. in Biology, Immunology, Biochemistry or related discipline
  • Experience with mammalian and bacterial cell culture
  • Experience with the following molecular biology techniques:
    • PCR, gel electrophoresis, gel imaging
    • Molecular cloning 
    • Bacterial transformation, culture, plating
    • Nucleic acid preparation (DNA, RNA)
    • qPCR
  • ELISA or related protein quantitation assays
  • Excellent organizational skills and being able to multitask
  • Excellent oral and written communication skills
  • Ability to work collaboratively with team members

Preferred Skills
  • Imaging and image analysis skills
  • Experience with flow cytometry
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