Akouos is building a leading gene therapy company focused on hearing disorders. We are a precision genetic medicine company focused on developing gene therapies with the potential to restore, improve and preserve high-acuity physiologic hearing for people worldwide who live with disabling hearing loss.
Restoring, improving and preserving high-acuity hearing is an area of high unmet need in medicine: 466 million people worldwide have disabling hearing loss, and there are no FDA-approved therapies to address its underlying causes.
Akouos was founded in 2016 by leaders in the fields of neurotology, genetics, inner ear drug delivery, and AAV gene therapy. Listening is in our DNA. We believe the only way to achieve our ambitious goals is to engage as one team, listen to each other, and trust in ourselves and our science.
The Anatomy & Physiology team is seeking a Scientist with experience in inner ear histology to support nonclinical discovery and IND-enabling animal studies. The scope of work includes designing and/or overseeing histology protocol development, preparation and histological analysis of nonclinical specimens, and the associated reporting. The individual will be self-motivated, with a desire to succeed at the highest level, working with a team of scientists aiming to develop therapies that have the potential to restore and preserve hearing.
- Planning, designing, executing, and analyzing preclinical studies in in vivo and/or ex vivo models of murine and NHP cochlear gene therapy.
- Perform inner ear tissue processing, including cochlear wholemount dissections and sectioning of frozen tissue.
- Perform immunohistochemical preparations of inner ear tissues.
- Perform epifluorescence and confocal microscopy.
- Perform necropsy / tissue harvest from rodents and tissue harvest from NHPs.
- Collaborate closely with cross-disciplinary teams and external groups to coordinate and drive complex studies
- Interpret histology data and clearly communicate results in written and oral formats.
To perform this job successfully, an individual must be able to perform each essential duty. The requirements listed below are representative of the knowledge, skill, and/or ability required.
- PhD in neuroscience (or equivalent experience) and a minimum of 3 years of hands on experience working in a laboratory environment; biotech or biopharma industry preferred.
- Experience with large animal and murine cochlear microdissections.
- Knowledge of cochlear anatomy and methods for histological preparation of inner ear tissues.
- Experience with microtome and cryostat sectioning.
- Experience with epifluorescence and confocal microscopy.
- Excellent analytical and problem-solving skills.
- Highly creative, organized, and detail-oriented.
- Proven ability to work as a member of an interdisciplinary team and contribute in a highly collaborative matrix environment.
- Excellent written and oral communication skills with the ability to thoroughly document, interpret, and effectively present scientific data.
- High energy and passion for drug discovery and development.
- Excellent computer skills and Microsoft Products proficiency (Outlook, Excel, Word, PowerPoint, etc.).