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Scientist, Antibody Engineering and CAR T-Cell Immunologist

Cambridge, MA
We make healthy cells invisible to targeted therapies

Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.

At Vor, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.

These eHSCs give rise to generations of new healthy blood cells that are effectively invisible to targeted therapies. Diseased cells displaying the target protein and are then vulnerable to attack. This process potentially broadens the therapeutic window and improves the utility of complementary targeted therapies.

Vor Biopharma is thrilled to have been chosen as the 2019 Xconomy Cell Therapy Platform of the year. We are well-funded by 5AM Ventures and RA Capital, among others. Please visit our website at https://www.vorbiopharma.com/ for more information.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines
Fellowship: Fostering genuine bonds of collaboration and mentorship
Humility: Acting selflessly by putting the collective mission first

As an equal opportunity employer, we at Vor Biopharma know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.

Who we are looking for
The successful candidate will contribute to advancing Vor’s targeted therapy approach. This will involve working within a team environment to execute experimental plans requiring fundamental skills in protein engineering of Chimeric Antigen Receptors (CAR) and handling of primary cell transduction protocols.

Key areas of responsibility:
  • Engineer CAR constructs from primary antibody sequences
  • Routinely perform culture and manipulation of primary cells and cell lines
  • Conduct cell-based assays such as flow cytometry to evaluate phenotypic changes in PBMCs and T cell lines
  • Characterize T cell functionality with cell-based assays (MSD, ELISA, cytotoxicity)
  • Lead the design of experiments, interpretation of data, and oversee troubleshooting with oversight from senior scientific personnel
  • Generate standard operating procedures, work instructions, test methods, study protocols, and technical reports
  • Prepare presentations and progress reports at regular internal research meetings
  • Maintain a clear, detailed laboratory notebook to document all experiments and findings
  • Comply with best safety practices
Qualifications:
  • PhD in fields such as biochemistry, molecular biology, immunology, cancer biology, or related discipline with 3+years of post-PhD experience is required
  • Experience with protein engineering, preferably Chimeric Antigen Receptors
  • Experience following cell transduction protocols (lentivirus, retrovirus, transposon)
  • Experience with in vitro cellular assays is highly desirable
  • Excellent communication, organization, and technical writing skills
  • Strong problem-solving skills and the ability to work independently in a startup environment
  • Immediate availability
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