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Scientist/Senior Scientist, Non-Viral Delivery & Platform Innovation

Boston, MA
Company Description:
Intergalactic Therapeutics is a bio-innovation company developing, delivering, and democratizing novel non-viral gene therapies for patients. Intergalactic’s proprietary synthetic c3DNA construct has the potential to deliver transformative therapeutic intervention for unmet medical needs and at a cost enabling global accessibility.

Summary:
The Molecular Design and Delivery group at Intergalactic Therapeutics is seeking a highly driven and innovative Scientist/Senior Scientist with expertise in non-viral or viral delivery of nucleic acid therapeutics. The successful candidate will play an integral role in developing Intergalactic’s proprietary non-viral delivery platforms in support of the advancement of truly differentiated gene therapies. This person will report to Jodi Kennedy, our Senior Director of Molecular Design & Delivery.
 
Expertise in protein biochemistry, biophysical methods, and drug delivery sciences required.
 
Key Responsibilities:
  • Design, optimize, and implement new drug delivery concepts for development and delivery of safe and efficacious gene therapies
  • Understand scope and limitations of current therapeutic delivery strategies and overcome them
  • Work closely with members of Molecular Design, Drug Discovery, In Vivo Pharmacology, and Analytical Sciences to discover novel non-viral delivery technologies in support of the advancement of Intergalactic’s therapeutic programs and non-viral delivery platform(s)
  • Develop, optimize and implement a panel of robust and reliable in vitro assays for screening and assessment of gene delivery vehicles and process optimizations
  • Participate in method development and technology innovation efforts to progress and extend our technology platform into novel applications
  • Provide leadership and training to junior scientists and oversee day-to-day activities as needed
  • Deliver on key milestones within defined timelines
Qualifications:
  • Ph.D. in Biophysical Chemistry, Chemistry, Biophysics, Biology, Bioengineering or related field with 0-5 years of relevant postdoctoral or industrial experience
  • Expertise in at least one of the following drug delivery systems: lipid nanoparticles, polymersomes, protein-based nanoparticles, nanoparticle functionalization/targeting, non-immunogenic surface engineering, or lipid/polymer biophysics
  • Experience using a variety of bioanalytical and biophysical tools to assess protein: nucleic acid interactions required (for e.g., fluorescence spectroscopy, DSC, ITC, FTIR, UV/Vis spectroscopy, AUC, SPR, HPLC)
  • Experience in protein/capsid engineering highly desired
  • Experience/Desire to mentor and train Research Associates as needed
  • Proactive and collaborative mindset, exhibiting an enthusiastic team attitude
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