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Associate Scientist/Scientist, Biochemistry

Cambridge, MA · Science/Research
Company Overview

Tango is an oncology biotechnology company focused on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We have inverted the traditional discovery paradigm with our target discovery platform, where the discovery of novel targets and the associated patient selection strategy are integrated into a single experimental design. Our platform uses cutting-edge CRISPR technologies to identify novel targets for genetically-defined groups of cancer patients. We leverage the principles of synthetic lethality to find novel dependencies in cancer cells and identify the relevant drug targets. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments as identified in the target discovery profess, thereby enabling greater speed, success, and impact for those patients.

Job Summary:

Tango Therapeutics is seeking an enthusiastic and highly self-motivated research associate to join our Biochemistry group. The successful candidate will be an integral member of a dynamic and multidisciplinary drug discovery team dedicated to developing drugs for a novel class of therapeutics. The candidate will be responsible for developing biochemical/biophysical assays for novel targets and generating high-quality data to support early drug discovery activities including hit finding, validation and optimization. In addition, the candidate will be involved in mechanism of inhibition studies and presenting summarized data to different teams. Ultimately, the candidate will also set up relationships with external partners to support the company drug discovery portfolio. 
Job Responsibilities:
  • Design and execute biochemical and biophysical medium throughput assays to characterize protein and protein-ligand interaction using standard screening technologies such as but no limited to TR-FRET, AlphaScreen/AlphaLisa, SPR, MST, DSF and MS-based detection
  • Collaborate with external partner for the development of high-throughput assays
  • Validate hits from screening efforts and provide support for hit-to-lead and lead optimization activities
  • Conduct experiments to determine mechanism of inhibition with lead molecules
  • Communicate, engage and build positive relationships with external research at CROs 
  • Analyze, interpret and present data to project team
  • Good laboratory management
  • Review literature and the findings of other researchers and attend conferences
  • Document data using ELN
Skills and Qualifications:
  • B.S/M.S. in biochemistry or a related discipline with 5+ plus years of research laboratory experience
  • Ability to design and conduct experiments independently in a fast-paced start-up environment
  • Solid understanding of enzyme kinetics and thermodynamics
  • Experience with developing and running biochemical assays
  • Experience with developing and running biophysical assays
  • Experience in protein expression/purification and routine cell assays is strongly preferred
  • Excellent attention to detail and strong documentation skills
  • Ability to communicate results to diverse audiences
  • Strong interpersonal and collaboration skills
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