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Associate/Senior Associate Scientist, Cell Biology

Cambridge, MA
We make healthy cells invisible to targeted therapies

Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.

At Vor, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.

These eHSCs give rise to generations of new healthy blood cells that are effectively invisible to targeted therapies. Diseased cells still display the target protein and are therefore vulnerable to attack. This process potentially broadens the therapeutic window and improves the utility of complementary targeted therapies.

Vor Biopharma is thrilled to have been chosen as the 2019 Xconomy Cell Therapy Platform of the year. We are well-funded by 5AM Ventures and RA Capital, among others. Please visit our website at https://www.vorbiopharma.com/ for more information.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines
Fellowship: Fostering genuine bonds of collaboration and mentorship
Humility: Acting selflessly by putting the collective mission first

As an equal opportunity employer, we at Vor Biopharma know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Who we are looking for
The successful candidate will contribute to advancing Vor’s engineered hematopoietic stem cell products. This will involve working within a team environment to execute experimental plans requiring skills in fundamental cellular biology, cellular engineering, and hematopoietic stem cell biology.

Key areas of responsibility:
  • Routinely perform culture, editing and manipulation of primary cells and cell lines
  • Conduct cell-based assays such as flow cytometry to evaluate phenotypic changes in gene modified cells
  • Implement sensitive genome-wide assays for various types of mutations and chromosomal rearrangements
  • Processing of cells and tissues from xeno-transplanted animals
  • Participate in the design of experiments, the interpretation of data, and lead troubleshooting with oversight from senior scientific personnel
  • Participate in drafting standard operating procedures, work instructions, test methods, study protocols, and technical reports
  • Participate in drafting presentations and progress at regular internal research meetings
  • Maintain a clear, detailed laboratory notebook to document all experiments and findings
  • Comply with best safety practices
Qualifications:
  • Bachelor’s or Master’s Degree in fields such as immunology, cancer biology, cellular biology, or related discipline is required (title and compensation commensurate with experience)
  • Bachelor’s Degree with 3+ years’ experience, or; Master’s Degree with 2+ years of laboratory experience in an academic or industry setting (industry preferred)
  • Experience with mammalian cell culture, preferably primary cells
  • Experience using gene editing tools (CRISPR, TALEN, or ZFN) preferred
  • Experience with in vitro cellular assays is highly desirable and experience with in vivo transplant models is a plus
  • Excellent communication, organization, and technical writing skills
  • Strong problem-solving skills and the ability to work independently in startup environment
  • Immediate availability
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