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Scientist, Cancer Biology

Cambridge, MA · Science/Research
Company Overview

Tango is an oncology biotechnology company with focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We have inverted the traditional discovery paradigm with our target discovery platform, where the discovery of novel targets and the associated patient selection strategy are integrated into a single experimental design. Our platform uses cutting-edge CRISPR technologies to identify novel targets for genetically-defined groups of cancer patients. We leverage the principles of synthetic lethality to find novel dependencies in cancer cells and identify the relevant drug targets. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments as identified in the target discovery profess, thereby enabling greater speed, success, and impact for those patients.
 
Job Summary

We are seeking a motivated and scientifically rigorous scientist to perform laboratory-based research in a collaborative, multidisciplinary team environment. The successful candidate will have experience in assay development and biological target validation, utilizing genetic and pharmacological perturbants in mammalian cell culture to discover and confirm candidates for novel therapeutics. You will also be involved in mechanism-of-action studies, the interpretation and presentation of data, and will function as an integral member of the team to advance novel cancer therapeutic targets.
 
Job Responsibilities
  • Develop and perform target engagement, pharmacodynamic and functional cellular assays to support drug discovery efforts
  • Conduct mammalian cell culture-mediated genetic perturbation studies using RNAi and/or CRISPR, as well as pharmacological perturbation studies to validate biological targets
  • Perform mechanism-of-action studies, including analysis of gene expression, pathway expression, protein levels, and or/or target activity levels, to validate and advance targets
  • Communicate and engage with contract research organizations
  • Independently summarize, analyze and present work to project and senior leadership teams; document data using ELN
  • Conduct research on underlying mechanisms relevant to cancer combination therapies, indication expansion and drug resistance
Skills & Qualifications
  • BS/MS in Molecular or Cell Biology, or related field, with a minimum of four years relevant industry experience
  • Expertise with genetic perturbation (e.g. CRISPR and/or RNAi) and genetic rescue techniques required
  • Familiar with oncogenic pathways, targeted and immunotherapies
  • Expertise with mammalian cell culture techniques required
  • Experience with protein detection methods (e.g. Western immunoblot and ELISA) required
  • Isolation and manipulation of RNA and DNA required
  • Flow cytometry and FACS experience is favorably considered
  • Ability to work in a cross-functional team environment, and a flexible team-oriented perspective is essential
  • Understanding of how to troubleshoot assays is required; experience working with CROs strongly preferred
  • Strong attention to detail and the ability to multi-task required
  • Strong verbal and written communication skills required
  • Knowledge of cancer biology pathways is favorably considered
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