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Associate Director/Director, Program Management

Cambridge, MA · Science/Research
Company Overview

Tango is an oncology biotechnology company with focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We have inverted the traditional discovery paradigm with our target discovery platform, where the discovery of novel targets and the associated patient selection strategy are integrated into a single experimental design. Our platform uses cutting-edge CRISPR technologies to identify novel targets for genetically-defined groups of cancer patients. We leverage the principles of synthetic lethality to find novel dependencies in cancer cells and identify the relevant drug targets. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments as identified in the target discovery profess, thereby enabling greater speed, success, and impact for those patients.

Job Summary:

Tango Therapeutics is seeking a Program Manager to guide our oncology drug discovery programs as we move exciting targets toward and into the clinic. This individual will be responsible for managing drug discovery programs in collaboration with program leaders (PL) across the organization. They will develop integrated drug discovery plans to drive selection of clinical candidates for oncology clinical development. Tango is a highly-collaborative organization, so the successful candidate will be comfortable working in teams and collaborating with team members of all levels.

Job Responsibilities:
  • Provides operational leadership for drug discovery of small molecule cancer therapeutics through development candidate selection and, clinical Proof of Concept (POC)
  • Supports the PL in the development of the program strategy and selection of the development candidate (DC) by planning and tracking activities in lead optimization, pharmacology, toxicology and ADME studies, preclinical work for patient selection and indication expansion, drug supply and formulation development
  • Achieves organizational alignment and seamless execution of the integrated drug discovery plans by working cross functionally within Tango and with CROs
  • Coordinates the preparation of presentations for Tango’s Board of Director meetings
  • Represents, as needed, the program team to discussions with management, scientific founders and Tango directors
  • Supports the alliance manager in the preparation for Joint Steering Committee Meetings for partnered programs
  • Leads the team in the assembly of program plans and budgets. Tracks the program budget and works with department heads to ensure headcount allocations match workload for the programs
  • Tracks program progress against the plan, working with department heads to identify and resolve resource constraints consistent with corporate priorities
  • Establishes, together with the PL, program and personal goals that are aligned with corporate goals 
  • Schedules, facilitates, and documents program team and ad-hoc program meetings; ensures uniformity between programs including agendas, meeting minutes and other program documentation
  • Identifies, tracks and supports resolution efforts for all program-related issues. Relays positive and negative deviations from program plans to the program team and management
  • Facilitates resolution of conflicts between functional groups while maintaining objectivity
  • Builds team spirit and positive team environment
  • Supports VP of Portfolio Management with the preparation and conduct of the R&D Portfolio meeting
Skills & Qualifications:
  • Doctoral degree in life sciences with 7+ years industry experience (or applicants with BS or MS and 12+ years in a pharmaceutical or biotech company)
  • Strong scientific background in Biology, Chemistry, or other area of drug discovery with at least 5 years of experience with multi-functional drug discovery program teams
  • Expert knowledge of drug discovery
  • Oncology experience strongly preferred 
  • Must have the ability to motivate others, prioritize multiple tasks, and maintain positive interpersonal skills
  • Excellent written and verbal communication.  Must be able to clearly present and communicate complex program information in both formal and informal settings
  • Good conflict resolution and problem-solving skills are a must
  • Must demonstrate good leadership and team building skills
  • Computer skills including Microsoft Program and Microsoft Office are required
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